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Association of urinary triclosan and methyl-triclosan levels with predictive indicators of cardiovascular disease and obesity in children and adolescents in 2020 (case study: Kerman, Iran)
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Habibeh Nasab    , Moghaddameh Mirzaee , Karim Ebrahimpour , Majid Hashemi |
| Corresponding author: Environmental Health Engineering Research Center, Kerman University of Medical Sciences, Kerman, Iran , mhashemi120@gmail.com |
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Abstract: (2437 Views) |
Background: Exposure of children and adolescents to endocrine disrupting chemicals (EDCs) causes the development of non-communicable diseases. Triclosan (TCS) is a fat-soluble antimicrobial agent, and methyl-triclosan (MTCS) is the predominant metabolite of TCS. The increasing use of consumables TCS (toothpaste, mouthwash, personal care products) in human has raised concerns about human health.
Methods: The urinary concentrations of TCS and MTCS were measured by GC/MS. Lipid profiles (TG, TC, LDL, and HDL), anthropometric parameters (WC, BMI z-score, and BMI), FBS, SBP, and DBP tests were performed on 79 children and adolescents.
Results: Of 79 people included as the study population, 42 subjects (53.16%) were males. Most of the study population as 32 subjects (40.50%) were obese. The mean concentrations of TCS and MTCS in the obese population were 5.47 ± 2.99 and 2.32 ± 1.04 µg/L, respectively. After adjusting for possible confounding factors, the results showed that a one-unit increase in DBP caused a 0.03 units increase in TCS levels in male subjects (P = 0.01). A one-unit increase in DBP also caused a 0.02 units increase in MTCS (P = 0.001). There was a significant relationship between TCS and HDL (OR = 0.90, P = 0.005), LDL (OR = 1.13, P = 0.01), and TG (OR =1.05, P < 0.0001). There was also a significant relationship between MTCS and HDL (OR = 0.88, P = 0.001), LDL (OR = 1.03, P = 0.009), and TG (OR = 1.04, P < 0.0001).
Conclusion: According to the results, there is a relationship between TCS, MTCS, and predictive indicators of cardiovascular diseases and obesity. |
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Keywords: Triclosan, Methyl triclosan, Cardiovascular disease, Obesity, Endocrine disrupter, Children, Adolescent
eprint link: http://eprints.kmu.ac.ir/id/eprint/38221 |
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Full-Text [PDF 378 kb]
(1060 Downloads)
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Type of Study: Original Article |
Subject:
Special
Received: 2021/08/2 | Accepted: 2021/08/1 | Published: 2021/09/26
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