en تخصصي Special مقاله اصیل Original Article <div style="text-align: justify;">Background: SARS-CoV was first identified in 2003 but SARS-CoV-2, which gained its recognition again in 2019 as COVID-19, has been a crucial threat worldwide and has caused more death rates than the SARS-CoV but till now no confined treatments are available. The present study aimed to investigate the efficacy of camphene against various structural and functional mutants of SARS-CoV-2 using reverse docking protocol.<br> Methods: To investigate the efficacy of camphene as a potential antiviral drug against COVID-19, against of all possible target proteins in SARS-CoV-2, which could lead to a new platform for drug discovery. Reverse pharmacology (Reverse docking) approach was performed, which involved docking of camphene and 20 structural and non-structural proteins (NSPs) of SARS-CoV-2 performed using maestro 12.8 of Schr&ouml;dinger.<br> Results: The results were evaluated since the minimum binding energy obtained after docking and camphene was effective against most of the proteins responsible for SARS-CoV-2, but camphene showed greater efficacy against the main protease (protease 9), which is main functional protein of<br> SARS-CoV-2. Hence, the study proves that camphene can be a good drug candidate for different mutants of SARS-CoV-2.<br> Conclusion: Protease 9, which is the main functional protein of SARS-CoV-2, expressed the best binding affinity with camphene having the minimum binding energy (-5.616). Hence, it is concluded that camphene could be the drug contender against protease 9 as it is a more potent target in SARSCoV-2. This could be a major finding, as camphene is related to camphor, which is already very beneficial against many respiratory problems.<br> <br> &nbsp;</div> SARS-CoV-2, Functional mutants, Reverse pharmacology, Binding affinity, Drug discovery 123 129 http://ehemj.com/browse.php?a_code=A-10-1-298&slc_lang=en&sid=1 Mahendra Kumar Savita mks.kanpur1@gmail.com 100319475328460013528 100319475328460013528 No Naraina Vidyapeeth Engineering and Management Institute, Kanpur, UP, India -208020 Neha Bora nehabora144@gmail.com 100319475328460013529 100319475328460013529 No Institute of Forensic Science and Criminology, Bundelkhand University, Jhansi, U.P. 284128, India Ruby Singh rubys922@gmail.com 100319475328460013530 100319475328460013530 Yes Corresponding author: Crazy fox creation, Vineet Khand, Gomti Nagar, Lucknow, UP, India-226010 Prachi Srivastava psrivastava@amity.edu 100319475328460013531 100319475328460013531 No Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow Campus 226028, India