en عمومى General مقاله اصیل Original Article <div style="text-align: justify;">Background: Metronidazole (MNZ) is a widely used pharmaceutical compound that has recently emerged as a significant environmental contaminant. Due to its potential mutagenic properties, MNZ poses risks of DNA damage and carcinogenesis.<br> Methods: This experimental study was conducted at the laboratory scale to investigate the efficiency of MNZ removal in aqueous solutions using a novel combination of ultrasonic waves (US), hydrogen peroxide (H₂O₂), and peroxymonosulfate (PMS).<br> Results: In the US/PMS/H2O2 process, the removal efficiency ranged from 4.3% to 99.5% under the best conditions (PMS dose = 6 mmol/L, H2O2 dose = 20 mmol/L, time = 30 min, US power = 120 W, MNZ concentration = 2 mg/L). A comparative analysis of the maximum removal efficiency between the two processes showed that incorporating US significantly increased MNZ removal, resulting in a 3-fold increase in efficiency under different conditions. Furthermore, in the PMS/H₂O₂ process, the H₂O₂ dose exerted the most pronounced impact, followed sequentially by reaction time, PMS dosage, MNZ concentration, and pH. In the US/PMS/H₂O₂ process, reaction time was identified as the most influential factor, followed by MNZ concentration, PMS dosage, US power, and H₂O₂ dosage. The results of the Taguchi design model further underscored the substantial contribution of ultrasonic irradiation to MNZ removal.<br> Conclusion: Overall, the findings demonstrate that US treatment is highly effective at significantly reducing MNZ concentrations in water and wastewater, highlighting the critical importance of parameter optimization in developing efficient US-based treatment technologies.</div> Ultrasonics, Peroxymonosulfate, Hydrogen peroxide, Wastewater, Water 1 12 http://ehemj.com/browse.php?a_code=A-10-1-431&slc_lang=en&sid=1 Zeinab Didari hejrandidari@gmail.com 100319475328460021296 0009-0007-7952-4243 No Student Research Committee, Department of Environmental Health Engineering, Faculty of Health, Isfahan University of Medical Sciences, Isfahan, Iran Ensiyeh Taheri e_taheri_83@yahoo.com 100319475328460021297 100319475328460021297 No Department of Environmental Health Engineering, Environmental Research Center, Non-Communicable Disease Prevention Research Institute, Health School, Isfahan University of Medical Sciences, Isfahan, Iran Hamidreza Pourzamani hamidpourzamani@gmail.com 100319475328460021298 100319475328460021298 Yes Correspondence to: Department of Environmental Health Engineering, Environmental Research Center, Non-Communicable Disease Prevention Research Institute, Health School, Isfahan University of Medical Sciences, Isfahan, Iran