Environmental Health Engineering and Management Journal
Environmental Health Engineering and Management Journal
Environ. Health Eng. Manag.
Medical Sciences
http://ehemj.com
1
admin
2423-3765
2423-4311
8
7
14
8888
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en
jalali
1401
10
1
gregorian
2023
1
1
10
1
online
1
fulltext
en
Metal exposure and breast malignancy: A case-control study of Malwa Region of Punjab
عمومى
General
مقاله اصیل
Original Article
<div style="text-align: justify;">Background: Breast cancer is triggered by uncontrollable breast cell development. These metals may build up in human serum and tissues, causing estrogenic/malignant consequences. Therefore, metals are being studied to investigate whether they enhance the risk of endocrine-related malignancies like breast cancer.<br>
Methods: This study assessed the level of metals such as Cd, As, Pb, Ni, Cr, Zn, and Fe in 120 women undergoing breast cancer surgery in the Malwa region of Punjab. Subjects having malignant breast lesions (n = 83) were grouped in the cancer case group whereas subjects with benign breast lesions (n = 37) were separated as a control group. From each case, blood, breast tumor, surrounding adipose tissue samples were obtained, and metal analysis was carried out using inductively coupled plasma mass spectrometry (ICP-MS).<br>
Results: In malignant cases, the amount of metals ranges from 0.04 to 139.18 μg/kg in tumor. Whereas in adipose tissues and blood, it ranges from 0.04 to 1164.0 μg/kg and from 0.02 to 276.61 μg/kg, respectively. In control group, the total amount ranges from 0.05 to 332.72 μg/kg in the tumor, from 0.13 to 125.61 μg/kg in adipose tissues, and from 0.01 to 121.76 μg/kg in the blood. The level of Cd, Cr, Zn, Fe, Ni, and Pb were observed to be statistically significant/extremely significant whereas Arsenic was detected in no groups.<br>
Conclusion: The results indicate that Cd, Cr, Zn, Fe, Ni, and Pb may play a significant role in the development of breast cancer. The parenchymal component of tumor tissues accumulates heavy metals at a higher rate.</div>
Breast neoplasms, Lead, Zinc, Cadmium, Carcinogenesis
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96
http://ehemj.com/browse.php?a_code=A-10-1-286&slc_lang=en&sid=1
Akriti
Sharma
Akriti.7799@gmail.com
100319475328460011682
100319475328460011682
Yes
Corresponding author: Department of Chemistry, University Institute of Sciences, Chandigarh University, Mohali, Punjab, India
Nidhi
Rani Gupta
nidhigupta0508@gmail.com
100319475328460011683
100319475328460011683
No
Department of Chemistry, Multani Mal Modi College, Patiala, Punjab, India
Nishtha
Hooda
27nishtha@gmail.com
100319475328460011684
100319475328460011684
No
Department of Computer Science and Engineering, Indian Institute of Information Technology, Una, Himachal Pradesh, India
Renu
Sharma
hod.chemistry.uis@cumail.in
100319475328460011685
100319475328460011685
No
Department of Chemistry, University Institute of Sciences, Chandigarh University, Mohali, Punjab, India