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:: Volume 8, Issue 4 (Autumn 2021) ::
Environ. Health Eng. Manag. 2021, 8(4): 309-318 Back to browse issues page
Detection to trace aluminum ion of pharmaceutical wastewater using synthesis of Schiff-based chemosensor
Mengistu Jemberu Dagnaw , Mahesh Gopal
Corresponding author:Department of Mechanical Engineering, Institute of Engineering and Technology, Wollega University, Post Box No.395, Nekemte, Ethiopia , mengejembe@gmail.com
Abstract:   (688 Views)
Background: The aim of this research was to develop a fluorogenic sensor for Al3 + ions, which have been identified as a possible food and drinking water pollutant by the WHO and considered to be harmful to human health.
Methods: The sensing mechanism was based on excited-state intramolecular proton transfer, with the intramolecular rotation restriction occurring after binding with the analyte. The probe attaches Al3 + selectively and emits strong emission in 4:1 H2O/MeOH (v/v) solution while irradiated at 400 nm in the presence of a wide number of cations, acting as a “turn-on” fluorescence chemosensor. The range of detection for Al3 + is 3.3 nM (3 method), which is more than 200 times more responsive than the WHO suggested limit of 7.4 mM (3σ method). Mass spectra, job plot, and Benesi-Hildebrand plot were used to determine the formation of the 1:1 metal-to-ligand complex.
Results: Aluminum (Al) ion content in effluent obtained from the pharmaceutical sector is 0.381 mM, which is a trace amount. A separate in vitro experiment indicates that the probe can precisely perceive Al3 + ions in a cell line. The sensor-based method is developed to detect 3.3 nM of Al3 + ions, which is significantly less than the WHO max.
Conclusion: The probe to detect Al3 + ions in live cells. HL becomes a flexible sensor for recognizing intracellular Al3 + in human liver cancer cell line Hep G2 and human lung fibroblast cell lines by fluorescence cell imaging procedures, and the probe’s non-toxicity has been proven by MTT tests up to 100M.
Keywords: Environment, Water, Pollution, Poisoning, Alzheimer’s, Parkinson’s dementia, Disease, Pharmaceutical, Aluminium, Fluorescence chemosensor, India
eprint link: http://eprints.kmu.ac.ir/id/eprint/38739
Full-Text [PDF 1268 kb]   (282 Downloads)    
Type of Study: Original Article | Subject: General
Received: 2021/12/12 | Accepted: 2021/11/1 | Published: 2021/12/12
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Jemberu Dagnaw M, Gopal M. Detection to trace aluminum ion of pharmaceutical wastewater using synthesis of Schiff-based chemosensor. Environ. Health Eng. Manag.. 2021; 8 (4) :309-318
URL: http://ehemj.com/article-1-856-en.html

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Volume 8, Issue 4 (Autumn 2021) Back to browse issues page
مجله مدیریت و مهندسی بهداشت محیط Environmental Health Engineering And Management Journal
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